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Saturday, 31 of July of 2010

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Estrogen and Migraines

Estrogen is known as a primary sex hormone for female. The estrogen -or oestrogens – is a group of steroid compounds named for their importance in the oestrus cycle. The level of estrogen for women is higher than that of a male especially if the woman is in her reproductive age.

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Estrogen helps in the development of secondary sex characteristics of women including breast, thickens the endometrium and regulates the menstrual cycle. Other functions of estrogen includes maintenance of vessel and skin, increases bone formation, increases hepatic production of binding proteins, increases salt and water retention, increases cholesterol in bile, reduces bower motility, decreases low-density-lipoprotein (LDL) and increases high-density-lipoprotein (HDL), triglyceride and fat deposits.

The life cycle of estrogen starts during infancy and childhood wherein the estrogen level is low. As the child matures, the estrogen level also increases and reaches an unusually high level after the first menstrual cycle. After the first menstrual cycle, estrogen level stabilizes until the perimenopausal – before menopause – stage is reached. During the perimenopausal period, the estrogen level again becomes variable and sometimes higher than the normal estrogen level. Then, estrogen level gradually lowers as the woman approached menopause stage. The low level is maintained throughout the postmenopausal stage. Studies have shown that low level of estrogen causes migraines or chronic headaches. The recurring headaches are usually experienced by women during their menstrual cycle, perimenopausal and menopausal stage. Aside from migraines, women also experience other low estrogen-related symptoms such as hot flashes, vaginal dryness, dizziness, fatigue, irritability and sweating. Because of the intense and frequent occurrence of migraines in women during their menopausal stage, hormone replacement therapy was studied and recommended by medical professionals. The therapy also aims to correct the estrogen level, to remedy migraine and to prevent osteoporosis. It was also believed that estrogen prevents heart attacks and maintains the youthful and sex drive of women. A study conducted by Women’s Health Initiative (WHI) revealed disturbing results. One of the study used estrogen only for the therapy. The study was not finished. There was more harm than benefits observed. The study showed that estrogen therapy increased the risk of stroke, increased deep vein thrombosis and did not prevent heart attacks especially for women who had undergone hysterectomy. Increased strokes, breast cancer, heart attacks and blot clotting were experienced by women who used estrogen with low dosage of medroxyprogesterone. As women age and reach the age of 52, estrogen will likely cause more harm than benefits. There are different forms of estrogen other than pills such as creams, gels and patches. These forms are not generally recognized as safe and effective even if less clotting occurs since the liver is not stimulated.  Still an unapproved new drug, labeling any cosmetics as hormone is said to be subjected to regulatory action. For osteoporosis, progesterone is recommended instead of estrogen. When migraine headaches occur, estrogen and progesterone are recommended to be taken daily. And for women who have used estrogen, it is recommended that a gradual removal of estrogen-related therapy be done when women age 52 and above.

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